What Is Nexium?
Nexium (esomeprazole) is a proton siphon inhibitor (PPI) accessible to individuals with stomach corrosive related conditions like gastroesophageal reflux sickness (GERD). As well as treating GERD in grown-ups and kids, Nexium can assist with forestalling stomach ulcers brought about by prescriptions, contamination, and other causes.
Esomeprazole comes in postponed discharge containers, deferred discharge granules, tablet structure, and powder for oral suspension.
Nexium is accessible as a professionally prescribed drug. In any case, you can purchase Nexium 24HR over-the-counter (OTC) in a lower dose structure to treat continuous indigestion (at least two days every week). It is likewise accessible in a nonexclusive structure.
- Drug Facts
- Nonexclusive Name: Esomeprazole
- Brand Name(s): Nexium
- Drug Availability: Prescription, over the counter
- Helpful Classification: Gastrointestinal specialist
- Accessible Generically: Yes
- Controlled Substance: N/A
- Organization Route: Oral
- Dynamic Ingredient: Esomeprazole
- Measurements Form(s): Tablet, container, bundle
What Is Nexium Used For?
Nexium is shown to treat or forestall specific conditions brought about by the inordinate creation of stomach corrosive, specifically:
GERD: A constant problem described by reflux, spewing forth, indigestion, hacking, roughness, chest torment, and inconvenience gulping
NSAID-related peptic ulcers: Peptic ulcers brought about by the drawn-out utilization of nonsteroidal calming drugs (NSAIDs) like anti-inflammatory medicine, Advil (ibuprofen), and Aleve (naproxen)
H. pylori annihilation: Prevention of the repeat of ulcers in patients going through anti-microbial treatment to destroy H. pylori (a bacterial disease firmly connected to peptic ulcers)
Hypersecretory problems: Rare stomach related issues like Zollinger-Ellison condition that outcome in the overproduction of stomach corrosive
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Grown-ups can involve Nexium for:
Four to about two months to treat GERD manifestations
As long as a half year to lessen the danger of NSAID-related stomach ulcers
Treatment of H. pylori
Long haul treatment of conditions that cause an excessive amount of stomach corrosive creation
Nexium can likewise be utilized in kids and young people year to 17 years old for as long as about two months to treat GERD. Youngsters ages multi-month to under 1 year can take Nexium for as long as about a month and a half just to treat GERD with corrosive related harm to the throat. Nonetheless, in kids under 1-year-old, studies showed it was not more viable than fake treatment following a month of treatment.
OTC Nexium 24HR is demonstrated for grown-ups with regular indigestion.
Instructions to Take Nexium
Grown-ups and kids as youthful as multi-month-old enough can utilize Nexium. Contingent upon your treatment objectives, you may take Nexium for somewhere in the range of 10 days (for H. pylori annihilation treatment) to as long as a half year (to forestall NSAID-related ulcers).
Nexium comes in two unique structures, each with explicit signs and dosing directions.
Deferred Release Capsules
Take the postponed discharge cases no less than one hour before a feast, normally one time per day, toward the beginning of the day. Gulp down the containers; don't bite or pound them.
Youngsters and grown-ups who experience difficulty gulping pills can open the container and sprinkle the substance over the fruit purée and burn it that way. This should be taken just after blend; don't put something aside for some time in the future. Try not to blend Nexium in with some other food aside from fruit purée. Different sorts of food varieties have not been assessed with Nexium, so it isn't known whether they may meddle with the medication's retention.
For patients with nasogastric taking care of cylinders, blend the substance of the Nexium case with 50 milliliters (mL) of water and infuse it into the cylinder with a needle. In particular, directions state it ought to just be controlled this way with a catheter-tipped syringe.
Deferred Release Granules
You can take Nexium deferred discharge granules the same way as Nexium containers. Blend the granules in with water to make a fluid suspension.
How much water used to break down the granules differs by the portion:
2.5-milligram (mg) and 5-mg parcels: Mix with 5 mL of water, sit tight for a few minutes to thicken, and burn-through inside 30 minutes.
10-mg, 20-mg, and 40-mg parcels: Mix with 15 mL of water, sit tight for a few minutes to thicken, and burn-through inside 30 minutes. On the off chance that there is buildup left in the cup, blend a limited quantity of water in and take what's left to guarantee the exactness of dosing.
Capacity
Nexium cases and granules can be put away securely at room temperature (around 77 degrees F). If voyaging, it is OK to open the medication to temperatures somewhere in the range of 59 and 86 degrees F for a brief period.
Keep the drugs in a cool, dry cabinet or bureau away from direct daylight. Store Nexium cases in their unique light-safe, water/airproof holder. The washroom is definitely not a decent spot to keep prescriptions.
Assuming Nexium is conveyed using a nasogastric tube, be certain that the medication is completely disintegrated before use. To try not to obstruct, flush the cylinder with extra water later the Nexium portion has been conveyed.
Off-Label Uses
Nexium and other PPIs are normally utilized off-mark, which means they are utilized to treat different conditions not indicated by the FDA.
Off-mark employments of esomeprazole include:
- Peptic ulcer illness (by any cause)
- Ongoing gastritis (by any cause)
- Dyspepsia (indigestion)
- Erosive esophagitis
- Barrett's esophagus
- Eosinophilic esophagitis
- Hiatal hernia (which frequently causes corrosive reflux)
- Stress gastritis (stomach aggravation) anticipation
- Cystinosis
See your medical care supplier assuming your reflux side effects don't resolve with moderate therapy, for example, diet or OTC medications. Heartburn can be brought about by numerous things—going from acid reflux to gastric disease. Getting a legitimate finding guarantee you get the right treatment.
How Long Does Nexium Take to Work?
You should begin to see an improvement in side effects a few days in the wake of starting Nexium, yet it can require as long as about a month for it to work appropriately.
What Are the Side Effects of Nexium?
This is certifiably not a total rundown of aftereffects, and others might happen. A clinical expert can prompt you on aftereffects. If you experience different impacts, contact your drug specialist or a clinical expert. You might report secondary effects to the FDA at www.fda.gov/medwatch or 1-800-FDA-1088.
Likewise, with all medications, Nexium might cause incidental effects. A considerable lot of these secondary effects are gentle and will resolve all alone as your body adjusts to treatment. Now and again, Nexium can cause genuine secondary effects. In any case, this generally happens in individuals with other ailments.
Before beginning Nexium, enlighten your medical care supplier regarding any ailments you have, including liver sickness, kidney illness, or mineral and bone issues like osteoporosis.
Normal Side Effects
Normal symptoms of Nexium can shift depending on your age and may include:
- Migraine
- The runs
- Queasiness
- Gas
- Stomach torment
- Dry mouth (chiefly in grown-ups)
- Obstruction (principally in grown-ups)
- Sluggishness (principally in youngsters)
- Disgorging (principally in infants)
- Fast breathing (principally in infants)
- Call your medical services supplier assuming these manifestations endure or deteriorate.
Serious Side Effects
Certain individuals taking Nexium have been known to foster intense interstitial nephritis. Intense interstitial nephritis is a fiery condition that can impede kidney work and even lead to intense kidney disappointment. It can happen at any phase of treatment and requires the prescription to be halted right away. The condition is accepted to be brought about by an easily affected medication reaction.
Nexium might expand the danger of bacterial contamination called Clostridium difficile (C. difficile) in hospitalized patients. C. difficile regularly spreads through clinics, causing watery looseness of the bowels, migraine, fever, queasiness, loss of hunger, and stomach pain.1 It is indistinct why this happens, yet it is imagined that PPIs permit C. difficile to flourish by diminishing the stomach acids that assist with keeping the microorganisms in check.
Intubated patients regularly get PPIs like Nexium to forestall gastric ulcers. Notwithstanding their advantages, the medications might expand the danger of pneumonia. This is because any pathogenic microscopic organisms that structure in the stomach might conceivably move to the lungs.
Serious medication sensitivities with Nexium, like touchy responses and hypersensitivity, are rare.
These incorporate side effects of hypersensitivity or anaphylactic shock, such as:
- Unexpected hives or rash
- Trouble relaxing
- Snugness of the throat
- Quick heartbeat
- Quick, shallow relaxing
- Expanding of the face, tongue, or throat
- Discombobulation or blacking out
- Sickness or retching
- A sensation of looming destruction
Contact your medical care supplier immediately if you have genuine incidental effects in the wake of utilizing Nexium. Call 911 assuming that your manifestations feel dangerous or on the other hand on the off chance that you believe you're having a health-related crisis.
Long haul Side Effects
PPIs like Nexium can build the danger of bone breaks, especially with long-haul use in more seasoned adults. PPIs are believed to be connected to an expanded danger of osteoporosis. In any case, studies are clashing on the real chances of this occurring.
Talk with your medical care supplier about ways of forestalling bone mineral misfortune and break, including the utilization of nutrient D or calcium supplements.
On uncommon events, PPIs like Nexium can cause a serious drop in blood magnesium levels, an occasion called hypomagnesemia. Hypomagnesemia will in general happen following an extended period of utilization however may begin as right on time as 90 days. Even though hypomagnesemia regularly has no indications, it can in some cases cause issues and fits, unusual heart rhythms (arrhythmia), and seizures.
Hypomagnesemia is normally treated with magnesium supplements and promptly ends the PPI.
Report Side Effects
Nexium might cause opposite secondary effects. Call your medical services supplier assuming you have any strange issues while taking this medicine.
Assuming you experience a genuine aftereffect, you or your supplier might send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting Program or by telephone (1-800-332-1088)
Dose: How Much Nexium Should I Take?
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The portion of this medication will be distinctive for various patients. Follow your physician's instructions or the headings on the mark. The accompanying data incorporates just the normal portions of this medication. Assuming your portion is unique, don't transform it except if your PCP advises you to do as such.
How much medication that you take relies upon the strength of the medication. Additionally, the number of dosages you require every day, the time permitted among portions, and the time allotment you take the medication rely upon the clinical issue for which you are utilizing the medication.
For oral measurement structures (cases or suspension):
To forestall NSAID-related gastric ulcers:
Grown-ups—20 or 40 milligrams (mg) when daily for as long as a half year. Your primary care physician might change your portion if on a case by case basis.
Youngsters—Use and portion should be controlled by your primary care physician.
To treat duodenal ulcers with H. pylori disease:
Grown-ups—40 milligrams (mg) when daily for 10 days. The portion is generally taken along with amoxicillin and clarithromycin. Your primary care physician might change your portion on a case-by-case basis.
Youngsters—Use and portion should be controlled by your PCP.
To treat erosive esophagitis:
Grown-ups—20 or 40 milligrams (mg) when daily for to about two months. Your primary care physician might change your portion on a case-by-case basis. To keep erosive esophagitis from returning, your PCP might need you to require 20 mg once every day for as long as a half year.
Kids 12 to 17 years old—20 or 40 milligrams (mg) when daily for to about two months. Your primary care physician might change your portion on a case-by-case basis.
Kids 1 to 11 years old and gauging 20 kilograms (kg) or more—10 or 20 mg once every day for quite some time. Your primary care physician might change your portion depending on the situation.
Youngsters 1 to 11 years old and weighing under 20 kg—10 mg once per day for quite a long time. Your primary care physician might change your portion depending on the situation.
Kids multi-month to under year old enough and gauging more than 7.5 kg to 12 kg—10 mg once every day for as long as about a month and a half. Your PCP might change your portion on a case-by-case basis.
Youngsters multi-month to under 1 year old enough and gauging more than 5 kg to 7.5 kg—5 mg once every day for as long as about a month and a half. Your primary care physician might change your portion depending on the situation.
Kids multi-month to under 1 year old enough and gauging 3 kg to 5 kg—2.5 mg once per day for as long as about a month and a half. Your PCP might change your portion on a case-by-case basis.
Newborn children are more youthful than multi-month-old enough—Use and portion should be dictated by your primary care physician.
To treat gastroesophageal reflux illness (GERD):
Grown-ups—20 milligrams (mg) when daily for quite some time. Your primary care physician might change your portion depending on the situation.
Youngsters 12 to 17 years old—20 milligrams (mg) when daily for quite a long time. Your PCP might change your portion depending on the situation.
Kids 1 to 11 years old—10 milligrams (mg) when daily for as long as about two months. Your primary care physician might change your portion on a case-by-case basis.
Youngsters are more youthful than 1 year old enough—Use and portion should be dictated by your PCP.
To treat Zollinger-Ellison disorder:
Grown-ups—40 milligrams (mg) 2 times each day. Your PCP might change your portion on a case-by-case basis.
Kids—Use and portion should be dictated by your PCP.
For oral dose structure (deferred discharge 24-hour cases):
To treat indigestion:
Grown-ups—20 milligrams (mg) when daily for 14 days.
Kids—Use and portion should be controlled by your PCP.
Alterations
Esomeprazole is separated by the liver and passed from the body essentially in the stool. Along these lines, patients with debilitated liver capacity are less ready to separate the medication and need a lower portion to keep away from liver harmfulness and injury.
If you have extreme liver hindrance—delegated Child-Pugh Class C—you should take something like 20 mg of Nexium each day to forestall these possibly genuine intricacies. Your medical services supplier ought to control liver capacity tests (LFTs) regularly to screen for any indications of hepatotoxicity (liver poisoning).
There is no proof to recommend that Nexium can't be utilized during pregnancy. Be that as it may, creature studies have revealed a potential for fetal imperfections. No all-around controlled investigations in people are accessible, however, there has been no proof of birth absconds in people. Creature studies propose that Nexium might cause bone distortion whenever taken at multiple times the suggested portion.
Assuming you are pregnant or considering getting pregnant, talk with your medical services supplier to completely gauge the therapy advantages and possible dangers. A similar applies if breastfeeding. Nexium might go through bosom milk in little quantities.
Missed Dose
Assuming you miss a portion of Nexium, accept it when you recollect. Assuming it is nearly an ideal opportunity for your next portion, skirt the underlying portion and proceed as ordinary. Never bend overdoses.
Glut: What Happens If I Take Too Much Nexium?
Unintentionally taking more than the suggested portion of Nexium (for instance, two 40-mg dosages in 24 hours) likely won't cause you any harm.
Be that as it may, a purposeful excess of up to 2,400 mg—multiple times the greatest portion in grown-ups—has been known to cause a large number of similar manifestations usually connected with Nexium, yet more harshly.
Side effects of a Nexium glut include:
- Drowsiness
- Cerebral pain
- Sickness
- Disarray
- Flushing
- Dry mouth
- Quick heartbeat
Obscured vision
Treatment of a Nexium glut depends on the side effects. There are no cures for a PPI excess, and methodology like hemodialysis can't clean the medication off of the circulatory system.
What Happens If I Overdose On Nexium?
Assuming you think you or another person might have ingested too much of Nexium (esomeprazole), call a medical care supplier or the Poison Control Center (1-800-222-1222).
Assuming somebody falls or isn't breathing in the wake of taking esomeprazole, call 911 right away.
Precautionary measures
Drug Content Provided and Reviewed by IBM Micromedex
Your doctor actually must really look at your or your kid's advancement at customary visits. This will permit your primary care physician to check whether the medication is working appropriately and to choose if you should keep on taking it. Blood, pee, and other lab tests might be expected to check for undesirable impacts. Assuming your condition doesn't improve, or on the other hand on the off chance that it turns out to be more regrettable, check with your primary care physician.
This medication is once in a while given along with amoxicillin (Amoxil®) and clarithromycin (Biaxin®) to treat ulcers brought about by H. pylori disease. Be certain you comprehend the dangers and legitimate utilization of some other meds your PCP endorses.
Check with your PCP immediately assuming you have an adjustment of recurrence of pee or measure of pee, blood in the pee, fever, joint agony, loss of hunger, queasiness, skin rash, expanding of the body, feet, or lower legs, surprising sluggishness or shortcoming, or uncommon weight gain in the wake of utilizing this medication. These could be manifestations of a genuine kidney issue called intense tubulointerstitial nephritis.
Taking this medication for quite a while may make it harder for your body to ingest nutrient B12. Let your PCP know if you have worries about nutrient B12 lack.
This medication might cause the runs, and sometimes it very well may be serious. Try not to take any medication to treat looseness of the bowels without first checking with your PCP. Check with your primary care physician immediately assuming you have a watery stool that doesn't disappear, stomach agony, and fever with this medication.
This medication might build you the danger of having cracks in the hip, wrist, and spine. This is almost certain assuming you are 50 years old and more established, utilize high dosages, or use it for one year or more. Summon your primary care physician right on the off chance that you have a serious bone tormentor can't walk or sit regularly.
This medication might cause hypomagnesemia (low magnesium in the blood). This is bound to happen on the off chance that you are involving this medication for over one year, or then again assuming you are utilizing it along with digoxin (Lanoxin®) or certain diuretics (water pills). Check with your PCP immediately assuming you have (seizures), a quick, hustling, or lopsided heartbeat, muscle fits (tetany), quakes, or surprising sluggishness or shortcoming.
Cutaneous or fundamental lupus erythematosus may happen or deteriorate in lupus patients and are taking PPI. Summon your primary care physician right assuming you or your youngster have a joint aggravation or skin rash on your cheeks or arms that deteriorates when uncovered in the sun.
This medication might build your danger for fundic organ polyps (strange tissue development in the upper piece of your stomach). This is almost certain if you are involved with this medication for over 1 year. Converse with your primary care physician assuming you have concerns.
Try not to quit utilizing this medication without first checking with your PCP.
Ensure any specialist or dental specialist who treats you realizes that you or your kid are utilizing this medication. This medication might influence the aftereffects of specific clinical trials.
Try not to take different drugs except if they have been examined with your primary care physician. This incorporates solution (eg, clopidogrel, atazanavir, nelfinavir, Plavix®, Reyataz®, Viracept®) or nonprescription (over-the-counter [OTC]) prescriptions and natural (eg, St. John's wort) or nutrient enhancements.
What Are Reasons I Shouldn't Take Nexium?
You ought not to utilize Nexium assuming you have a known extreme touchiness to any PPI. This incorporates having encountered sensitivity instigated bronchospasm, urticaria (hives), angioedema (profound tissue enlarging), intense interstitial nephritis, or hypersensitivity.
What Other Medications Interact With Nexium?
Nexium has a few medication drug connections, some of which are more critical than others.
Nexium can associate with:
- Antifungals like ketoconazole and voriconazole
- CellCept (mycophenolate mofetil)
- Warfarin
- Digoxin
- Methotrexate
- Plavix (clopidogrel)
- Pletal (cilostazol)
- Protopic (tacrolimus)
- Reyataz (atazanavir)
- Rifampin
- Tarceva (erlotinib)
- Valium (diazepam)
You can keep away from a portion of these collaborations by isolating the dosages by a few hours. Others might require a portion change, a medication replacement, or the impermanent stopping of one of the drugs.
To stay away from cooperations, consistently tell your medical care group about any medications you take, incl
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